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The Future of Dieting

Copyright (c) 2007 Luke Burgis Researchers hope to start phase one
Look good naked without stepping a foot trials early next year and get the drug
in the gym. That's the new American on the market in three to five years.
dream right? We are a nation obsessed Y2R blocker - Georgetown University
with the eternal quest to look great with Medical Center researchers have been able
minimal to no effort. Whether you are to use nontoxic chemical injections to
just too busy to make it to the gym add and remove fat from lab mice. To add
everyday, or simply need that little fat, researchers injected the
extra help with your own diet and workout neurotransmitter NPY into the mice. It's
routine, there is good news on the believed that NPY is activated during
horizon for all of us, new drugs! These stress, causing apple-shaped obesity and
upcoming pharmaceutical releases are metabolic syndrome. But administration of
gearing up to take the fat loss market by the receptor Y2R into the mice's
storm over the next couple of years so abdominal fat prevented both results,
read up and get a head start on your melting the fat. Researchers hope that
beach body competition. blocking Y2R might work the same way in
Pramlintide - Already available in the humans.
U.S. as a diabetes treatment, Pramlintide Rimonabant (Acomplia) - Approved for use
is being studied by Amylin in the European Union as an obesity
Pharmaceuticals for its ability to treatment, rimonabant selectively blocks
produce a feeling of fullness when eating the CB1 receptors of the endocannabinoid
and reduce weight. A synthetic form of a system. This system of receptors in the
satiety hormone, research has shown that brain and body helps regulate food intake
when it's injected into people's bodies and how the body uses and stores fats and
before a meal they eat less, even when sugars. In clinical trials, rimonabant
given foods they crave. Amylin is also has been shown to reduce body weight,
looking at how the drug works in with side effects such as nausea and
combination with other hormones. anxiety. Sanofi-aventis withdrew its FDA
CP404 - CP404 is a calcium channel new drug application for rimonabant last
blocker that works as a nasal spray to month but is working toward resubmitting.
block olfactory activity, or our sense of Suppressing Rip140 - Research has shown
smell, and reduce food intake. Compellis that suppression of receptor-interacting
Pharmaceuticals is developing the drug, protein 140 (Rip140), a nuclear hormone
which has only been tested on mice so co-repressor that regulates fat
far, says Compellis CEO Chris Adams. The accumulation, can accelerate fat burning
company plans to begin human testing this in animals and fat cells. Initially the
year. subject of experiments at Imperial
Orlistat (Xenical and alli) - A lipase College in London, RXi Pharmaceuticals is
inhibitor, Orlistat promotes weight loss developing the approach as a potential
by preventing the digestion and obesity or type-2 diabetes treatment.
absorption of some fat from food. Cetilistat - Under development by
Unabsorbed fat is then excreted via the Alizyme, Cetilistat is a gastrointestinal
stool. It's available by prescription as lipase inhibitor that blocks fat
Xenical and, since June, as alli, the digestion and absorption, causing weight
only FDA-approved over-the-counter weight loss. Clinical trials have shown that the
loss product. Orlistat side effects may drug has fewer side effects than Xenical,
include gas with oily spotting and an according to Alizyme. Cetilistat is
urgent need to have a bowel movement currently being prepared for phase-three
CLA - A new meta-analysis by University clinical development.
of Wisconsin at Madison researchers has Meridia - An oral prescription
shown that supplements containing medication, Meridia works by affecting
conjugated linoleic acid (CLA), on the the appetite control center in the brain.
market for years, may help people shed Most people who lose weight on the drug,
fat. It's believed that CLA, a fatty acid in combination with diet and exercise, do
found in foods of animal origin such as so in the first six months of treatment,
beef, modifies enzymes responsible for according to its maker, Abbott
storing and burning fat. Supplements are Laboratories. Common side effects include
a good vehicle for CLA because it would headache, dry mouth, constipation and
be difficult for people to get enough of insomnia.
the fatty acid without loading up on So, have you scoped out the ones that
saturated fat. sound like the next big wonder drug?
PP - Researchers at the Imperial College, Well don't get too excited, these need a
London, are looking at how gut little more time before they are readily
hormones--pancreatic polypeptide (PP) in available to the public but keep your
particular--affect appetite control. The eyes peeled for them over the next few
hormones are released when a person eats, years. And remember that being healthy
acting as neurotransmitters that tell the is more than just a weight game. Be
brain to stop eating. Though it's being active, be fit, be healthy, and you will
developed in the form of an injection, look good naked. The ultimate goal
it's possible in the future that it could right?
be produced as a patch or gum.




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