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The Future of Dieting

Copyright  (c)  2007  Luke  Burgisget the drug on the market in three to five
years.
Look good naked without stepping a foot in
the gym. That's the new American dreamY2R blocker - Georgetown University Medical
right? We are a nation obsessed with theCenter researchers have been able to use
eternal quest to look great with minimal tonontoxic chemical injections to add and
no effort. Whether you are just too busy toremove fat from lab mice. To add fat,
make it to the gym everyday, or simply needresearchers injected the neurotransmitter NPY
that little extra help with your own diet andinto the mice. It's believed that NPY is
workout routine, there is good news on theactivated during stress, causing apple-shaped
horizon for all of us, new drugs! Theseobesity and metabolic syndrome. But
upcoming pharmaceutical releases are gearingadministration of the receptor Y2R into the
up to take the fat loss market by storm overmice's abdominal fat prevented both results,
the next couple of years so read up and get amelting the fat. Researchers hope that
head  start  on  your beach body competition.blocking Y2R might work the same way in
humans.
Pramlintide - Already available in the U.S.
as a diabetes treatment, Pramlintide is beingRimonabant (Acomplia) - Approved for use in
studied by Amylin Pharmaceuticals for itsthe European Union as an obesity treatment,
ability to produce a feeling of fullness whenrimonabant selectively blocks the CB1
eating and reduce weight. A synthetic form ofreceptors of the endocannabinoid system. This
a satiety hormone, research has shown thatsystem of receptors in the brain and body
when it's injected into people's bodieshelps regulate food intake and how the body
before a meal they eat less, even when givenuses and stores fats and sugars. In clinical
foods they crave. Amylin is also looking attrials, rimonabant has been shown to reduce
how the drug works in combination with otherbody weight, with side effects such as nausea
hormones.and anxiety. Sanofi-aventis withdrew its FDA
new drug application for rimonabant last
CP404 - CP404 is a calcium channel blockermonth  but  is  working  toward resubmitting.
that works as a nasal spray to block
olfactory activity, or our sense of smell,Suppressing Rip140 - Research has shown that
and reduce food intake. Compellissuppression of receptor-interacting protein
Pharmaceuticals is developing the drug, which140 (Rip140), a nuclear hormone co-repressor
has only been tested on mice so far, saysthat regulates fat accumulation, can
Compellis CEO Chris Adams. The company plansaccelerate fat burning in animals and fat
to  begin  human  testing  this  year.cells. Initially the subject of experiments
at Imperial College in London, RXi
Orlistat (Xenical and alli) - A lipasePharmaceuticals is developing the approach as
inhibitor, Orlistat promotes weight loss bya potential obesity or type-2 diabetes
preventing the digestion and absorption oftreatment.
some fat from food. Unabsorbed fat is then
excreted via the stool. It's available byCetilistat - Under development by Alizyme,
prescription as Xenical and, since June, asCetilistat is a gastrointestinal lipase
alli, the only FDA-approved over-the-counterinhibitor that blocks fat digestion and
weight loss product. Orlistat side effectsabsorption, causing weight loss. Clinical
may include gas with oily spotting and antrials have shown that the drug has fewer
urgent  need  to  have  a  bowel  movementside effects than Xenical, according to
Alizyme. Cetilistat is currently being
CLA - A new meta-analysis by University ofprepared for phase-three clinical
Wisconsin at Madison researchers has showndevelopment.
that supplements containing conjugated
linoleic acid (CLA), on the market for years,Meridia - An oral prescription medication,
may help people shed fat. It's believed thatMeridia works by affecting the appetite
CLA, a fatty acid found in foods of animalcontrol center in the brain. Most people who
origin such as beef, modifies enzymeslose weight on the drug, in combination with
responsible for storing and burning fat.diet and exercise, do so in the first six
Supplements are a good vehicle for CLAmonths of treatment, according to its maker,
because it would be difficult for people toAbbott Laboratories. Common side effects
get enough of the fatty acid without loadinginclude headache, dry mouth, constipation and
up  on  saturated  fat.insomnia.
PP - Researchers at the Imperial College,So, have you scoped out the ones that sound
London, are looking at how gutlike the next big wonder drug? Well don't
hormones--pancreatic polypeptide (PP) inget too excited, these need a little more
particular--affect appetite control. Thetime before they are readily available to the
hormones are released when a person eats,public but keep your eyes peeled for them
acting as neurotransmitters that tell theover the next few years. And remember that
brain to stop eating. Though it's beingbeing healthy is more than just a weight
developed in the form of an injection, it'sgame. Be active, be fit, be healthy, and you
possible in the future that it could bewill look good naked. The ultimate goal
produced as a patch or gum. Researchers hoperight?
to start phase one trials early next year and



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