| Copyright (c) 2007 Luke Burgis
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| | Researchers hope to start phase one
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| Look good naked without stepping a foot
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| | trials early next year and get the drug
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| in the gym. That's the new American
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| | on the market in three to five years.
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| dream right? We are a nation obsessed
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| | Y2R blocker - Georgetown University
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| with the eternal quest to look great with
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| | Medical Center researchers have been able
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| minimal to no effort. Whether you are
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| | to use nontoxic chemical injections to
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| just too busy to make it to the gym
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| | add and remove fat from lab mice. To add
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| everyday, or simply need that little
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| | fat, researchers injected the
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| extra help with your own diet and workout
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| | neurotransmitter NPY into the mice. It's
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| routine, there is good news on the
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| | believed that NPY is activated during
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| horizon for all of us, new drugs! These
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| | stress, causing apple-shaped obesity and
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| upcoming pharmaceutical releases are
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| | metabolic syndrome. But administration of
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| gearing up to take the fat loss market by
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| | the receptor Y2R into the mice's
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| storm over the next couple of years so
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| | abdominal fat prevented both results,
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| read up and get a head start on your
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| | melting the fat. Researchers hope that
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| beach body competition.
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| | blocking Y2R might work the same way in
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| Pramlintide - Already available in the
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| | humans.
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| U.S. as a diabetes treatment, Pramlintide
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| | Rimonabant (Acomplia) - Approved for use
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| is being studied by Amylin
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| | in the European Union as an obesity
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| Pharmaceuticals for its ability to
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| | treatment, rimonabant selectively blocks
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| produce a feeling of fullness when eating
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| | the CB1 receptors of the endocannabinoid
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| and reduce weight. A synthetic form of a
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| | system. This system of receptors in the
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| satiety hormone, research has shown that
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| | brain and body helps regulate food intake
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| when it's injected into people's bodies
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| | and how the body uses and stores fats and
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| before a meal they eat less, even when
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| | sugars. In clinical trials, rimonabant
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| given foods they crave. Amylin is also
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| | has been shown to reduce body weight,
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| looking at how the drug works in
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| | with side effects such as nausea and
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| combination with other hormones.
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| | anxiety. Sanofi-aventis withdrew its FDA
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| CP404 - CP404 is a calcium channel
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| | new drug application for rimonabant last
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| blocker that works as a nasal spray to
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| | month but is working toward resubmitting.
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| block olfactory activity, or our sense of
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| | Suppressing Rip140 - Research has shown
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| smell, and reduce food intake. Compellis
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| | that suppression of receptor-interacting
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| Pharmaceuticals is developing the drug,
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| | protein 140 (Rip140), a nuclear hormone
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| which has only been tested on mice so
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| | co-repressor that regulates fat
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| far, says Compellis CEO Chris Adams. The
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| | accumulation, can accelerate fat burning
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| company plans to begin human testing this
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| | in animals and fat cells. Initially the
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| year.
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| | subject of experiments at Imperial
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| Orlistat (Xenical and alli) - A lipase
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| | College in London, RXi Pharmaceuticals is
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| inhibitor, Orlistat promotes weight loss
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| | developing the approach as a potential
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| by preventing the digestion and
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| | obesity or type-2 diabetes treatment.
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| absorption of some fat from food.
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| | Cetilistat - Under development by
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| Unabsorbed fat is then excreted via the
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| | Alizyme, Cetilistat is a gastrointestinal
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| stool. It's available by prescription as
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| | lipase inhibitor that blocks fat
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| Xenical and, since June, as alli, the
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| | digestion and absorption, causing weight
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| only FDA-approved over-the-counter weight
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| | loss. Clinical trials have shown that the
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| loss product. Orlistat side effects may
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| | drug has fewer side effects than Xenical,
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| include gas with oily spotting and an
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| | according to Alizyme. Cetilistat is
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| urgent need to have a bowel movement
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| | currently being prepared for phase-three
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| CLA - A new meta-analysis by University
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| | clinical development.
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| of Wisconsin at Madison researchers has
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| | Meridia - An oral prescription
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| shown that supplements containing
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| | medication, Meridia works by affecting
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| conjugated linoleic acid (CLA), on the
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| | the appetite control center in the brain.
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| market for years, may help people shed
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| | Most people who lose weight on the drug,
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| fat. It's believed that CLA, a fatty acid
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| | in combination with diet and exercise, do
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| found in foods of animal origin such as
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| | so in the first six months of treatment,
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| beef, modifies enzymes responsible for
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| | according to its maker, Abbott
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| storing and burning fat. Supplements are
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| | Laboratories. Common side effects include
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| a good vehicle for CLA because it would
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| | headache, dry mouth, constipation and
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| be difficult for people to get enough of
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| | insomnia.
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| the fatty acid without loading up on
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| | So, have you scoped out the ones that
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| saturated fat.
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| | sound like the next big wonder drug?
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| PP - Researchers at the Imperial College,
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| | Well don't get too excited, these need a
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| London, are looking at how gut
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| | little more time before they are readily
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| hormones--pancreatic polypeptide (PP) in
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| | available to the public but keep your
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| particular--affect appetite control. The
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| | eyes peeled for them over the next few
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| hormones are released when a person eats,
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| | years. And remember that being healthy
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| acting as neurotransmitters that tell the
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| | is more than just a weight game. Be
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| brain to stop eating. Though it's being
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| | active, be fit, be healthy, and you will
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| developed in the form of an injection,
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| | look good naked. The ultimate goal
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| it's possible in the future that it could
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| | right?
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| be produced as a patch or gum.
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